Temporal regulation of natural killer T cell interferon gamma responses by β-catenin-dependent and-independent wnt signaling

JC Kling; MA Jordan; LA Pitt; J Meiners; T Thanh-Tran; LS Tran; TTK Nguyen; D Mittal; R Villani; RJ Steptoe; K Khosrotehrani; SP Berzins; AG Baxter; DI Godfrey; A Blumenthal

Journal article

Temporal regulation of natural killer T cell interferon gamma responses by β-catenin-dependent and-independent wnt signaling

JC Kling, MA Jordan, LA Pitt, J Meiners, T Thanh-Tran, LS Tran, TTK Nguyen, D Mittal, R Villani, RJ Steptoe, K Khosrotehrani, SP Berzins, AG Baxter, DI Godfrey, A Blumenthal

Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2018

DOI: 10.3389/fimmu.2018.00483

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Abstract

Natural killer T (NKT) cells are prominent innate-like lymphocytes in the liver with critical roles in immune responses during infection, cancer, and autoimmunity. Interferon gamma (IFN-γ) and IL-4 are key cytokines rapidly produced by NKT cells upon recognition of glycolipid antigens presented by antigen-presenting cells (APCs). It has previously been reported that the transcriptional coactivator β-catenin regulates NKT cell differentiation and functionally biases NKT cell responses toward IL-4, at the expense of IFN-γ production. β-Catenin is not only a central effector of Wnt signaling but also contributes to other signaling networks. It is currently unknown whether Wnt ligands regulate N..

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University of Melbourne Researchers

Stuart Berzins Author

Dale Godfrey Author

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported in part by a UQ Early Career Researcher grant (JK), funding by the University of Queensland Diamantina Institute (AB) and by the National Health and Medical Research Council of Australia (NHMRC projects 1013667 and 1113293). JK acknowledges support by a University of Queensland Postdoctoral Research Fellowship. MJ was supported by an MS Research Australia/National Health and Medical Research Council (NHMRC) Research Betty Cuthbert Fellowship. KK, AGB, and DG were supported by NHMRC Research Fellowships. AB acknowledges support by a Research Fellowship by the International Balzan Foundation.